منابع مشابه
Acetaminophen.
Acetaminophen is an effective mild analgesic and antipyretic agent. In double-blind, controlled experimental pain studies of short duration, acetaminophen is superior to placebo and produces analgesia comparable to that produced by aspirin. The frequency of adverse reactions to therapeutic doses of acetaminophen is low, as is that of aspirin. Overdosage with acetaminophen, however, may result i...
متن کاملAcetaminophen Poisoning
Acetaminophen is one of the most popular nonnarcotic analgesic–antipyretic agents available. Inappropriate use of this agent can lead to significant morbidity and mortality secondary to hepatic necrosis. Several patient-specific factors impact its metabolism and the subsequent production of its toxic metabolite when consumed in excess. Rapid diagnosis and treatment with N-acetylcysteine in the ...
متن کامل35 : Acetaminophen
By the late 1800s, both phenacetin and acetanilide were used as analgesics and antipyretics, but their acceptance was limited by significant side effects including methemoglobinemia. N-acetyl-p-aminophenol (APAP) is a major metabolite of phenacetin and acetanilide, and is responsible for, both analgesia and antipyresis. APAP was synthesized in 1878 and has a low risk of causing methemoglobinemi...
متن کاملAcetaminophen Analysis in Different Commercial Formulation of Iranian Acetaminophen Tablets
Acetaminophen is one of the most important antipyretic and analgesic drugs. It has an excellent efficacy when it's used in therapeutic doses, but in unsafe doses it can be resulted in hepatotoxicity and permanent liver failure. Due to disparities that have been reported between the actual and stated concentration of acetaminophen tablets, we aimed to compare the actual quantity of 8 Iranian gen...
متن کاملAcetaminophen-related hepatotoxicity.
Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). Single overdose ingestion and therapeutic misadventure may cause hepatotoxicity. Several factors, such as concomitant alcohol use or abuse, concurrent medications, genetic factors, and nutritional status, can influence the susceptibility and severity of APAP hepatotoxicity. Early manifestations o...
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ژورنال
عنوان ژورنال: The Professional Medical Journal
سال: 2018
ISSN: 2071-7733,1024-8919
DOI: 10.29309/tpmj/18.4807